Insertable heart monitor to catch early atrial fibrillation after catheter ablation
Official title: Insertable Cardiac Monitor-Guided Early Intervention to Reduce Atrial Fibrillation Burden Following Catheter Ablation (ICM-REDUCE-AF Trial)
Funded at University of Rochester · NIH-11176391 · Data updated 2026-11-12
This trial tests whether a small implanted heart monitor that finds early, often-silent atrial fibrillation and prompts early treatment can help people with drug-resistant atrial fibrillation after catheter ablation.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | July 1, 2021 |
| Project end | June 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $621,117 |
| NIH project number | 5R33HL153001-05 |
| Project ID | NIH-11176391 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with drug-refractory paroxysmal or persistent atrial fibrillation who are scheduled for catheter ablation and are willing to have an insertable cardiac monitor implanted are the ideal candidates.
✕Less likely to help
People who are not undergoing catheter ablation, who cannot have an implanted monitor, or who cannot attend required follow-up visits are unlikely to benefit from this trial.
What this research studies
You would have a small insertable cardiac monitor placed and be randomly assigned to either get early treatment guided by the monitor and a patient mobile app or to follow standard post-ablation care. The monitor continuously records your heart rhythm to detect subclinical atrial fibrillation you might not feel. The trial is double-blind to the subclinical monitoring data and will enroll about 120 patients at a single center. Researchers will compare how much atrial fibrillation occurs and whether early actions reduce recurrences over the follow-up period.
Why it matters
Potential benefit: If successful, this approach could reduce the amount of atrial fibrillation you experience after ablation and lower the need for repeat procedures or additional medications.
How similar studies have gone: Prior studies show catheter ablation can lower AF and insertable monitors reliably detect silent AF, but using continuous monitor-guided early intervention after ablation is a newer strategy that remains unproven.
Where this research is happening
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University of Rochester
Rochester, United States Active
Researchers
- Principal investigator: Goldenberg, Ilan — University of Rochester
- Study coordinator: Goldenberg, Ilan
Related research
Other NIH-funded projects on the same topics.
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Using a heart monitor to improve treatment outcomes for atrial fibrillation after catheter ablation
This study is looking at how a small heart monitor can help catch early signs of atrial fibrillation returning after treatment, so that people can get the right help sooner, and it’s for patients who have had catheter ablation for this condition.
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Using advanced imaging techniques to improve heart procedure outcomes for atrial fibrillation
This study is looking to make catheter ablation for atrial fibrillation more effective by using advanced imaging techniques to better understand heart anatomy, which could help doctors personalize treatment plans and improve results for patients like you.
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Evaluating a new treatment approach for atrial fibrillation using renal artery denervation.
This study is looking at whether combining a procedure called renal artery denervation with catheter ablation can help people with atrial fibrillation have better heart rhythm control and fewer episodes of AF.
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Cardiomyocyte-fibroblast signaling in atrial fibrillation
A researcher at Baylor College of Medicine is studying how signals between heart muscle cells and supportive heart cells influence atrial fibrillation, with the goal of finding new ways to prevent or treat this common heart rhythm problem.
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Anticoagulation in ICH Survivors with Atrial Fibrillation and Small Vessel Disease
This project looks at how to safely use blood-thinning medicines in people who survived a brain bleed and also have atrial fibrillation and small vessel disease.
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Lowering heart inflammation to reduce atrial fibrillation risk in people with diabetes
Seeing whether blocking a pro-inflammatory enzyme or boosting the heart's natural inflammation-resolving signals can lower atrial fibrillation risk in people with diabetes.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.