Insertable heart monitor to catch early atrial fibrillation after catheter ablation
Insertable Cardiac Monitor-Guided Early Intervention to Reduce Atrial Fibrillation Burden Following Catheter Ablation (ICM-REDUCE-AF Trial)
This trial tests whether a small implanted heart monitor that finds early, often-silent atrial fibrillation and prompts early treatment can help people with drug-resistant atrial fibrillation after catheter ablation.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11176391 on NIH RePORTER |
What this research studies
You would have a small insertable cardiac monitor placed and be randomly assigned to either get early treatment guided by the monitor and a patient mobile app or to follow standard post-ablation care. The monitor continuously records your heart rhythm to detect subclinical atrial fibrillation you might not feel. The trial is double-blind to the subclinical monitoring data and will enroll about 120 patients at a single center. Researchers will compare how much atrial fibrillation occurs and whether early actions reduce recurrences over the follow-up period.
Who could benefit from this research
Good fit: Adults with drug-refractory paroxysmal or persistent atrial fibrillation who are scheduled for catheter ablation and are willing to have an insertable cardiac monitor implanted are the ideal candidates.
Not a fit: People who are not undergoing catheter ablation, who cannot have an implanted monitor, or who cannot attend required follow-up visits are unlikely to benefit from this trial.
Why it matters
Potential benefit: If successful, this approach could reduce the amount of atrial fibrillation you experience after ablation and lower the need for repeat procedures or additional medications.
How similar studies have performed: Prior studies show catheter ablation can lower AF and insertable monitors reliably detect silent AF, but using continuous monitor-guided early intervention after ablation is a newer strategy that remains unproven.
Where this research is happening
Rochester, United States
- University of Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Goldenberg, Ilan — University of Rochester
- Study coordinator: Goldenberg, Ilan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.