Innovative therapy to reduce blood sugar levels in older adults
Official title: High-definition Endoscopic Ultrasound Navigation for Targeted Dual Neuromodulation Therapy
Funded at Reshape Lifesciences, INC. · NIH-10817376 · Data updated 2026-11-12
This study is testing a new treatment called Targeted Dual Neuromodulation Therapy to help manage blood sugar levels in kids and older adults at risk of Type 2 Diabetes, using a special system that targets nerves to improve how the body controls glucose.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Reshape Lifesciences, INC. NIH-funded |
| Lab location | 1 site (Irvine, UNITED STATES) |
| Project start | September 15, 2023 |
| Project end | September 14, 2025 |
| Funding year | 2023 |
| Award (this year) | $331,451 |
| NIH project number | 1R43DK136366-01A1 |
| Project ID | NIH-10817376 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include older adults and children who are either diagnosed with Type 2 Diabetes Mellitus or are prediabetic.
✕Less likely to help
Patients who do not have diabetes or prediabetes, or those with contraindications to neuromodulation therapies, may not benefit from this research.
What this research studies
This research investigates a new approach called Targeted Dual Neuromodulation Therapy (TDN Therapy) to help manage blood glucose levels in patients, particularly focusing on the elderly and children at risk of Type 2 Diabetes Mellitus. The therapy uses a closed-loop system that combines an implantable pulse generator, a continuous blood glucose monitor, and nerve leads to precisely target and modulate nerve activity related to blood sugar regulation. By employing high-definition endoscopic ultrasound, the researchers aim to accurately identify and place nerve leads, minimizing side effects and improving treatment outcomes. The study will first assess the feasibility of this approach in animal models before moving to human trials.
Why it matters
Potential benefit: If successful, this research could provide a safer and more effective treatment option for managing blood sugar levels in patients with diabetes.
How similar studies have gone: Preliminary studies have shown success in using endoscopic ultrasound for nerve imaging and manipulation, indicating potential for this novel approach.
Where this research is happening
-
Reshape Lifesciences, INC.
Irvine, United States Active
Researchers
- Principal investigator: Waataja, Jon James — Reshape Lifesciences, INC.
- Study coordinator: Waataja, Jon James
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.