Innovative therapy to improve blood sugar control in diabetes
Official title: Diabetic Targeted Dual Neuromodulation Parametric Optimization
Funded at Reshape Lifesciences, INC. · NIH-10920167 · Data updated 2026-11-12
This study is exploring a new way to help people with Type 2 Diabetes manage their blood sugar using a special therapy that sends gentle electrical signals to nerves, and it's designed to find the best settings for keeping blood sugar levels stable while being safe and effective.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Reshape Lifesciences, INC. NIH-funded |
| Lab location | 1 site (Irvine, UNITED STATES) |
| Project start | August 20, 2024 |
| Project end | August 19, 2025 |
| Funding year | 2024 |
| Award (this year) | $345,650 |
| NIH project number | 1R43DK137628-01A1 |
| Project ID | NIH-10920167 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Type 2 Diabetes Mellitus, particularly those who have not responded well to traditional therapies.
✕Less likely to help
Patients with Type 1 Diabetes or those who are not diagnosed with diabetes may not benefit from this research.
What this research studies
This research investigates a new treatment approach called Diabetes Targeted Dual Neuromodulation Therapy (TDN Therapy) aimed at improving blood glucose levels in patients with Type 2 Diabetes Mellitus (T2DM). The therapy involves implantable devices that use electrical signals to modulate nerve activity related to glucose control. By testing different signal amplitudes in animal models, the researchers aim to find the optimal settings that effectively manage blood sugar levels with minimal side effects. This approach seeks to provide a safer and more effective alternative to current diabetes treatments.
Why it matters
Potential benefit: If successful, this research could lead to a novel treatment option that improves blood sugar control for patients with Type 2 Diabetes Mellitus.
How similar studies have gone: While this approach is innovative, similar neuromodulation techniques have shown promise in other areas of diabetes management, indicating potential for success.
Where this research is happening
-
Reshape Lifesciences, INC.
Irvine, United States Active
Researchers
- Principal investigator: Waataja, Jon James — Reshape Lifesciences, INC.
- Study coordinator: Waataja, Jon James
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.