Innovative strategies for targeting immune responses in aging lymph nodes
Nano Immune-Imaging Core
['FUNDING_P01'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-11083585
This study is exploring new ways to improve the health of aging lymph nodes to help prevent transplant rejection in heart transplant patients by delivering treatments directly where they're needed and watching how immune cells behave.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11083585 on ClinicalTrials.gov |
What this research studies
This research focuses on developing advanced nanodelivery methods to modify the environment of aging lymph nodes, which are crucial for immune responses. By using targeted delivery of therapeutics, the project aims to inhibit the activation of harmful immune cells that can lead to transplant rejection. Additionally, it will utilize cutting-edge imaging techniques to track how immune cells interact within these lymph nodes. This approach could enhance the effectiveness of treatments for patients undergoing heart transplantation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals undergoing heart transplantation, particularly those who are older and may have age-related immune challenges.
Not a fit: Patients who are not undergoing transplantation or those with conditions unrelated to immune response or aging may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved transplant outcomes and reduced rejection rates for heart transplant patients.
How similar studies have performed: Previous research in nanomedicine and immune modulation has shown promising results, indicating that this approach could be effective in enhancing transplant tolerance.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ABDI, REZA — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: ABDI, REZA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.