Innovative reactions using chlorosilanes for creating complex organic molecules
Official title: Enantioselective Catalytic Chlorosilane Reactions
Funded at Florida Institute of Technology · NIH-10974556 · Data updated 2026-11-12
This study is exploring new ways to use special chemicals called chlorosilanes to create important building blocks for making new medicines, which could lead to better treatments for patients.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida Institute of Technology NIH-funded |
| Lab location | 1 site (Melbourne, United States) |
| Project start | August 1, 2020 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $434,607 |
| NIH project number | 2R15GM139087-02 |
| Project ID | NIH-10974556 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research include individuals with conditions that could be treated by new pharmaceutical compounds developed through these innovative chemical methods.
✕Less likely to help
Patients who are not seeking new treatment options or those with conditions that do not require novel drug therapies may not benefit from this research.
What this research studies
This research focuses on developing new chemical methods using chlorosilanes, which are reactive intermediates in organic synthesis. By employing Lewis base catalysts, the project aims to enhance the ability of chlorosilanes to deliver carbon nucleophiles, leading to the creation of novel chiral building blocks. The research combines experimental and computational approaches to explore challenging transformations and aims to synthesize biologically relevant molecules that are difficult to obtain with existing methods. Patients may benefit from advancements in drug development and the creation of new therapeutic agents derived from these innovative chemical processes.
Why it matters
Potential benefit: If successful, this research could lead to the development of new drugs and therapies that are more effective and easier to produce.
How similar studies have gone: While the specific approach of using chlorosilanes in this manner may be novel, similar methodologies in organic synthesis have shown promise in advancing drug development.
Where this research is happening
-
Florida Institute of Technology
Melbourne, United States Active
Researchers
- Principal investigator: Takenaka, Norito — Florida Institute of Technology
- Study coordinator: Takenaka, Norito
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.