Innovative radiation therapy for pancreatic cancer treatment
Official title: Project 2
Funded at Johns Hopkins University · NIH-11012039 · Data updated 2026-11-12
This study is looking at a new way to treat pancreatic cancer using a special type of radiation called FLASH, which delivers high doses to tumors while protecting healthy tissue, and combines it with immunotherapy to boost the body's immune response, all aimed at improving treatment results for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 20, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $204,240 |
| NIH project number | 1U54CA295336-01 |
| Project ID | NIH-11012039 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with pancreatic cancer who may benefit from advanced radiation therapy options.
✕Less likely to help
Patients with non-cancerous conditions or those who do not have pancreatic cancer may not receive any benefit from this research.
What this research studies
This research investigates a new approach called FLASH radiotherapy, which aims to treat pancreatic cancer by delivering ultra-high doses of radiation to tumors while minimizing damage to surrounding healthy tissues. The study explores the combination of FLASH radiotherapy with immunotherapy to enhance the immune response against both the treated tumor and any metastatic tumors. By using smart radiotherapy biomaterials, the project seeks to improve the delivery of immunotherapy, potentially leading to better patient outcomes. The research will also focus on establishing safety and effectiveness parameters for this new treatment method.
Why it matters
Potential benefit: If successful, this research could significantly improve survival rates and quality of life for patients with pancreatic cancer.
How similar studies have gone: Other research has shown promising results with FLASH radiotherapy, indicating its potential as a novel treatment approach.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Ngwa, Wilfred — Johns Hopkins University
- Study coordinator: Ngwa, Wilfred
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.