Innovative optical tools for studying biological processes
Official title: Next-generation optical nanoprobes: From quantum biosensing to cellular monitoring
Funded at Johns Hopkins University · NIH-11081015 · Data updated 2026-11-12
This study is working on new tools that help scientists see and understand what's happening inside our cells, which could lead to better ways to diagnose and treat diseases for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $409,375 |
| NIH project number | 5R35GM149272-03 |
| Project ID | NIH-11081015 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with conditions that involve complex cellular processes, such as cancer or neurodegenerative diseases.
✕Less likely to help
Patients with conditions that do not involve cellular or molecular analysis may not receive direct benefits from this research.
What this research studies
This research focuses on developing advanced optical tools that can visualize and measure complex biological processes at the cellular level. By creating new platforms that combine techniques like surface-enhanced Raman spectroscopy with nanoscale magnetometry, the project aims to enhance our ability to detect and analyze biomolecules in real-time. Patients may benefit from improved diagnostic techniques and targeted therapies that arise from a better understanding of cellular mechanisms. The research will also explore biomimetic structures to improve cellular analysis.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnostics and targeted treatments for various diseases.
How similar studies have gone: Other research has shown promise in using advanced optical techniques for cellular analysis, indicating a potential for success in this innovative approach.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Barman, Ishan — Johns Hopkins University
- Study coordinator: Barman, Ishan
Related research
Other NIH-funded projects on the same topics.
-
Targeting hidden brain injuries in iTTP to improve long-term brain health
A researcher aims to find out how silent brain injuries in people with immune thrombotic thrombocytopenic purpura (iTTP) happen, how they affect thinking and stroke risk, and how to prevent them.
-
Accelerated flap coverage for severe leg injuries: earlier reconstruction vs standard timing
This study tests whether doing early flap coverage after a severe leg injury lowers infection risk and improves healing for patients with open wounds and bone injury.
-
Placebo-controlled shunting for iNPH: does the surgery help with walking and balance?
A doctor-led trial at Johns Hopkins will test whether a shunt surgery improves walking and balance in older adults with idiopathic normal pressure hydrocephalus.
-
Omalizumab for COPD patients with allergen sensitization and exposure
A multicenter trial will test whether adding omalizumab helps people with COPD who are allergic to common indoor allergens and are exposed to them.
-
Johns Hopkins Total Worker Health Center focusing on mental health
A nationwide center at Johns Hopkins is working to improve mental health and well-being among workers by studying workplace health strategies and translating findings into practical tools.
-
Role of fat droplets in liver fat and inflammatory signals in NAFLD
A study at Johns Hopkins will explore how fat droplets in the liver influence molecules that drive inflammation and progression of non-alcoholic fatty liver disease (NAFLD) in adults.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.