Innovative methods for delivering gene therapy using adeno-associated viruses
Official title: Complementary Biotherapeutic Delivery Platforms for Enabling Gene Re-delivery
Funded at State University of Ny,binghamton · NIH-11137824 · Data updated 2026-11-12
This study is working on new ways to help gene therapy treatments work better for people by improving how the therapy is delivered and overcoming the body's immune response, making it easier for patients to benefit from these treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of Ny,binghamton NIH-funded |
| Lab location | 1 site (Binghamton, United States) |
| Project start | August 1, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $385,660 |
| NIH project number | 5R35GM155362-02 |
| Project ID | NIH-11137824 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients who have previously received gene therapy and are experiencing immune responses that limit its effectiveness.
✕Less likely to help
Patients who have not undergone gene therapy or those with conditions unrelated to AAV gene delivery may not benefit from this research.
What this research studies
This research focuses on developing new delivery platforms to improve the effectiveness of gene therapy using adeno-associated viruses (AAVs). It addresses the challenge of the immune system's response to these vectors, which can hinder their effectiveness. The project employs a multifaceted approach, including targeted delivery of regulatory T cells to specific sites and systems to remove neutralizing antibodies that block gene delivery. By enhancing the delivery mechanisms, the research aims to ensure that gene therapies can be more effectively administered and sustained in patients.
Why it matters
Potential benefit: If successful, this research could lead to more effective gene therapies for patients with conditions that require gene re-delivery.
How similar studies have gone: Other research has shown promise in enhancing gene therapy delivery methods, indicating that this approach could build on existing successes.
Where this research is happening
-
State University of Ny,binghamton
Binghamton, United States Active
Researchers
- Principal investigator: Mei, Kuo-Ching — State University of Ny,binghamton
- Study coordinator: Mei, Kuo-Ching
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.