Innovative chemical methods for labeling proteins in non-water environments
Official title: Chemical labeling strategies using biomolecule-compatible, nonaqueous media
Funded at North Carolina State University Raleigh · NIH-11135410 · Data updated 2026-11-12
This study is looking at new ways to change proteins using special chemicals in dry environments instead of water, which could help create better treatments for diseases by focusing on parts of proteins that are usually ignored.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | North Carolina State University Raleigh NIH-funded |
| Lab location | 1 site (Raleigh, United States) |
| Project start | July 15, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $369,178 |
| NIH project number | 5R35GM155051-02 |
| Project ID | NIH-11135410 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with conditions that could be treated or diagnosed using advanced protein labeling techniques.
✕Less likely to help
Patients with conditions unrelated to protein modifications or those who do not require therapeutic interventions based on bioconjugation may not benefit from this research.
What this research studies
This research focuses on developing new chemical labeling techniques that can effectively modify proteins in nonaqueous media, which is a significant advancement over traditional methods that rely on water. The approach aims to selectively target and label less common amino acids that are often overlooked in current bioconjugation technologies. By exploring the compatibility of nonaqueous environments with biomolecules, the research seeks to enhance the efficiency and specificity of protein modifications, which could lead to better therapeutic agents and improved understanding of disease mechanisms. Patients may benefit from advancements in treatments that arise from these innovative methods.
Why it matters
Potential benefit: If successful, this research could lead to more effective therapeutic agents and improved diagnostic tools for various diseases.
How similar studies have gone: While there have been advancements in bioconjugation technologies, this specific approach using nonaqueous media is relatively novel and has not been extensively tested.
Where this research is happening
-
North Carolina State University Raleigh
Raleigh, United States Active
Researchers
- Principal investigator: Ohata, Jun — North Carolina State University Raleigh
- Study coordinator: Ohata, Jun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.