Injecting stem cells to help children with a serious heart condition
1/2 Allogeneic Human Mesenchymal Stem Cell (MSC) Injection in Patients with Hypoplastic Left Heart Syndrome: A Phase IIb Clinical Trial
This study is looking at whether special stem cells can help improve heart function in children with Hypoplastic Left Heart Syndrome, a serious heart condition, and it's designed to find new treatment options for these kids.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lurie Children's Hospital of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10890142 on NIH RePORTER |
What this research studies
This research investigates the use of allogeneic human mesenchymal stem cells (MSCs) to treat children with Hypoplastic Left Heart Syndrome (HLHS), a complex congenital heart defect. The study involves a Phase IIb clinical trial where MSCs are injected into patients to assess their effectiveness in improving heart function. The research is conducted across multiple clinical sites, focusing on managing patient enrollment and overseeing the clinical design. By building on previous studies, this trial aims to provide a new treatment option for children who often face high mortality rates due to heart complications.
Who could benefit from this research
Good fit: Ideal candidates for this research are infants and young children diagnosed with Hypoplastic Left Heart Syndrome.
Not a fit: Patients with other congenital heart defects or those who are not within the age range of 0-11 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved heart function and survival rates for children with Hypoplastic Left Heart Syndrome.
How similar studies have performed: Previous studies using stem cell therapies in similar contexts have shown promise, suggesting potential for success in this trial.
Where this research is happening
Chicago, United States
- Lurie Children's Hospital of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Berger, Stuart — Lurie Children's Hospital of Chicago
- Study coordinator: Berger, Stuart
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.