Injectable microgels to release platelet-rich plasma for treating joint pain
Official title: Development of Injectable Super-Lubricious Microgels for Sustained Release of Platelet-Rich Plasma to Treat Post-Traumatic Osteoarthritis
Funded at Saint Louis University · NIH-11062525 · Data updated 2026-11-12
This study is testing a new injection that uses tiny particles filled with healing blood components to help relieve pain and improve joint health for people with post-traumatic osteoarthritis in their knees.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Saint Louis University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | May 10, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $478,467 |
| NIH project number | 5R01AR081270-03 |
| Project ID | NIH-11062525 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with post-traumatic osteoarthritis who are experiencing joint pain and dysfunction.
✕Less likely to help
Patients with osteoarthritis not related to trauma or those who have already undergone total joint replacement may not benefit from this research.
What this research studies
This research focuses on developing a new injectable treatment for post-traumatic osteoarthritis (PTOA), a painful joint condition affecting millions. The approach involves creating super-lubricious microspheres that contain platelet-rich plasma (PRP), which is derived from the patient's own blood and contains healing properties. By injecting these microspheres into the knee joint, the goal is to provide sustained release of PRP, helping to reduce inflammation and promote tissue regeneration. This method aims to overcome the limitations of current treatments that do not effectively address cartilage degeneration.
Why it matters
Potential benefit: If successful, this research could provide a more effective treatment option for patients suffering from post-traumatic osteoarthritis, potentially reducing pain and improving joint function.
How similar studies have gone: Other research has shown promise in using platelet-rich plasma for joint treatments, but this specific approach with super-lubricious microspheres is novel.
Where this research is happening
-
Saint Louis University
Saint Louis, United States Active
Researchers
- Principal investigator: Zustiak, Silviya Petrova — Saint Louis University
- Study coordinator: Zustiak, Silviya Petrova
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.