Inflammation's role in the growth of mutated blood stem cells in older adults
Inflammatory Stress Promotes Clonal Expansion of DNMT3A-mutant HSCs
This study is looking at how inflammation affects the growth of blood stem cells with a common mutation in older adults, especially those over 65, to help us understand more about blood diseases like myelodysplastic syndromes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11073085 on NIH RePORTER |
What this research studies
This research investigates how inflammation affects the growth of blood stem cells that have mutations associated with blood diseases, particularly in individuals aged 65 and older. The study focuses on a specific mutation in the DNMT3A gene, which is commonly found in older adults and can lead to conditions like myelodysplastic syndromes. By understanding the environmental factors, such as inflammation, that promote the expansion of these mutated stem cells, researchers aim to uncover new insights into the development of blood disorders. The approach involves examining how chronic inflammation influences the behavior of these mutated cells compared to normal stem cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 65 and older who may have mutations in their blood stem cells.
Not a fit: Patients under the age of 65 or those without mutations in their blood stem cells may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating blood diseases in older adults.
How similar studies have performed: Previous studies have shown that understanding the role of inflammation in blood disorders can lead to significant advancements in treatment, suggesting that this research could build on established findings.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Challen, Grant Anthony — Washington University
- Study coordinator: Challen, Grant Anthony
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.