Inflammation in pelvic nerves affecting bladder and erectile function after surgery
Official title: Pelvic ganglia inflammation as a factor leading to organ crosstalk and coordinated development of bladder and erectile dysfunction following pelvic surgery.
Funded at Albert Einstein College of Medicine · NIH-11073021 · Data updated 2026-11-12
This study is looking at how inflammation in the pelvic area after surgery, like prostate removal, might cause problems with bladder control and erections, and it hopes to find ways to help prevent these issues for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project start | April 15, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $675,090 |
| NIH project number | 5R01DK139328-02 |
| Project ID | NIH-11073021 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are men undergoing radical prostatectomy or similar pelvic surgeries who are at risk for bladder and erectile dysfunction.
✕Less likely to help
Patients who have not undergone pelvic surgery or those with pre-existing bladder or erectile dysfunction unrelated to surgical intervention may not benefit from this research.
What this research studies
This research investigates how inflammation in the pelvic ganglia may lead to both bladder and erectile dysfunction in patients who have undergone pelvic surgery, such as radical prostatectomy. The study uses animal models to explore the molecular changes and inflammatory responses that occur following surgery, even when nerve-sparing techniques are employed. By understanding these mechanisms, the research aims to identify potential therapeutic targets to prevent these complications. Patients may benefit from insights that could lead to improved surgical techniques or post-operative treatments.
Why it matters
Potential benefit: If successful, this research could lead to better management strategies for preventing bladder and erectile dysfunction in patients after pelvic surgery.
How similar studies have gone: Previous studies have indicated that inflammation can play a significant role in post-surgical complications, suggesting that this research builds on established findings but may explore novel mechanisms.
Where this research is happening
-
Albert Einstein College of Medicine
Bronx, United States Active
Researchers
- Principal investigator: Davies, Kelvin P — Albert Einstein College of Medicine
- Study coordinator: Davies, Kelvin P
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.