Inflammation in fat tissue may lead to liver disease in obese individuals
LIFR-alpha/JAK/STAT3-dependent Adipose Inflammation Contributes to Obesity-Associated NAFLD - Resubmissi
This study is looking at how inflammation in fat tissue affects the liver in people with obesity, and it’s exploring a special molecule called LIF to see if it can help us find new ways to treat liver problems related to being overweight.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11003679 on NIH RePORTER |
What this research studies
This research investigates how inflammation in adipose (fat) tissue contributes to the development of non-alcoholic fatty liver disease (NAFLD) in individuals with obesity. It focuses on the role of specific signaling molecules, particularly leukemia inhibitory factor (LIF), in altering fat cell behavior and promoting inflammation. By studying the interactions between different cell types in adipose tissue, the research aims to uncover mechanisms that could lead to new treatments for obesity-related liver conditions. The approach includes using animal models to observe changes in fat mass and inflammation when specific pathways are manipulated.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are obese and at risk for developing non-alcoholic fatty liver disease.
Not a fit: Patients who are not obese or do not have any metabolic conditions related to obesity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing or treating liver disease in obese patients.
How similar studies have performed: Previous research has shown that targeting inflammatory pathways in adipose tissue can lead to significant improvements in metabolic health, suggesting a promising avenue for this study.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Infante, Rodney E — Ut Southwestern Medical Center
- Study coordinator: Infante, Rodney E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.