Inducing immune tolerance for transplanted beta cells in type 1 diabetes
Local immune modulation for beta cell replacement therapy in type 1 diabetes
This study is looking for a way to help people with type 1 diabetes by finding a treatment that allows the body to accept new insulin-producing cells without attacking them, using special techniques to create more of these cells from stem cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-11052553 on NIH RePORTER |
What this research studies
This research aims to create a treatment for type 1 diabetes by inducing localized immune tolerance to transplanted human beta cells derived from stem cells. The approach involves preventing the immune system from rejecting these grafted cells in diabetic mice that mimic human immune responses. Researchers will also explore the biological mechanisms behind this therapy through in vitro studies. By using advanced techniques to generate an unlimited supply of functional beta cells, the project seeks to address the shortage of donor islets for transplantation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with type 1 diabetes who may benefit from beta cell replacement therapy.
Not a fit: Patients with type 2 diabetes or those who do not have a need for beta cell replacement may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a renewable source of insulin-producing beta cells for patients with type 1 diabetes, potentially reducing their dependence on insulin therapy.
How similar studies have performed: Previous research has shown promise in using stem cell-derived beta cells for transplantation, indicating that this approach has potential based on earlier successes.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Phelps, Edward — University of Florida
- Study coordinator: Phelps, Edward
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.