Indiana University Drug-Induced Liver Injury Network (DILIN)
IU Clinical Center: Drug Induced Liver Injury Network
This project invites adults with suspected drug-related liver injury to join efforts that collect health records and blood samples to learn what causes injury, who is at risk, and how recovery or harm happens.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-11168733 on NIH RePORTER |
What this research studies
If I join, the team will collect my medical records and follow my liver tests over time, using both new and past cases from Central Indiana. They work through Indiana University and the Regenstrief health information exchange to find and enroll people, with extra outreach to include racially and ethnically diverse patients. The center also runs two extra studies, including testing whether cell-free RNA in the blood can reveal drug-related liver damage. Participation may include clinic visits, blood draws, and permission to use past health data for research.
Who could benefit from this research
Good fit: Adults (21+) with suspected or recent idiosyncratic drug-induced liver injury, able to provide consent and share medical records, are ideal candidates.
Not a fit: People without any liver injury, those under 21, or patients whose liver problems are clearly due to non-drug causes are unlikely to benefit directly from joining.
Why it matters
Potential benefit: If successful, this work could help doctors diagnose drug-caused liver injury sooner, identify people at higher risk, and point toward better treatments.
How similar studies have performed: The DILIN network has enrolled patients since 2003 and produced important knowledge about drug-related liver injury, though some biomarker approaches like cell-free transcriptome testing are newer and less proven.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Chalasani, Naga P — Indiana University Indianapolis
- Study coordinator: Chalasani, Naga P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.