Increasing the number of blood stem cells from umbilical cord blood
Expand human umbilical cord blood hematopoietic stem cells with PPAR-a agonists
This study is looking at ways to increase the number of important blood stem cells from umbilical cord blood to make them more available for transplants, which can help people with blood-related illnesses.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Coriell Institute for Medical Research NIH-funded |
| Lab location | 1 site (Camden, United States) |
| Project ID | NIH-10954535 on NIH RePORTER |
What this research studies
This research focuses on enhancing the quantity of hematopoietic stem cells (HSCs) derived from umbilical cord blood using specific compounds known as PPAR-a agonists. By expanding these stem cells, the research aims to improve their availability for transplants, which are crucial for treating blood-related diseases and disorders. The approach involves utilizing cryopreserved umbilical cord blood samples to develop new methods for increasing the number of functional HSCs, potentially leading to better patient outcomes in stem cell transplants.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals requiring hematopoietic stem cell transplants, particularly those with blood malignancies or hypoproliferative disorders.
Not a fit: Patients who do not require stem cell transplants or have conditions unrelated to blood disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve the effectiveness and availability of stem cell transplants for patients with blood disorders.
How similar studies have performed: Previous studies have shown promise in expanding hematopoietic stem cells using various methods, indicating that this approach may build on established successes.
Where this research is happening
Camden, United States
- Coriell Institute for Medical Research — Camden, United States (Active)
Researchers
- Principal investigator: Huang, Jian — Coriell Institute for Medical Research
- Study coordinator: Huang, Jian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.