Increasing NAD levels to reduce inflammation in heart failure
Official title: Boosting NAD to Combat Heart Failure Sterile Inflammation
Funded at VA Puget Sound Healthcare System · NIH-10951523 · Data updated 2026-11-12
This study is looking at how increasing a substance called NAD+ might help lower inflammation in people with heart failure, which could lead to better treatments for this condition that affects many Americans.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Puget Sound Healthcare System NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | October 1, 2023 |
| Project end | September 30, 2028 |
| Funding year | 2025 |
| NIH project number | 5IK2BX006111-02 |
| Project ID | NIH-10951523 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with heart failure, particularly those experiencing chronic inflammation.
✕Less likely to help
Patients without heart failure or those whose condition is not linked to inflammation may not benefit from this research.
What this research studies
This research investigates how boosting levels of NAD+ can help reduce inflammation associated with heart failure (HF). Heart failure affects millions of Americans and is linked to chronic inflammation, which worsens patient outcomes. The study aims to understand the inflammatory signals involved in HF and how immune cells respond to them. By exploring the role of mitochondrial damage-associated molecular patterns (MitoDAMP) and the effects of NAD+ on inflammation, the research seeks to identify new therapeutic strategies for managing heart failure.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve the management of heart failure by reducing inflammation.
How similar studies have gone: Previous studies have shown promising results in reducing inflammation through NAD+ boosting, indicating potential for success in this novel approach.
Where this research is happening
-
VA Puget Sound Healthcare System
Seattle, United States Active
Researchers
- Principal investigator: Wang, Dennis Ding Hwa — VA Puget Sound Healthcare System
- Study coordinator: Wang, Dennis Ding Hwa
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.