Increasing muscle mass to improve blood vessel function in obesity
Official title: Increasing muscle mass resolves vascular dysfunction in obesity
Funded at Augusta University · NIH-10910867 · Data updated 2026-11-12
This study is looking at how building muscle can improve blood vessel problems caused by obesity, especially for people who might find it hard to exercise, and it aims to find new ways to help treat health issues related to being overweight.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Augusta University NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project start | August 1, 2023 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $42,512 |
| NIH project number | 5F31HL165858-02 |
| Project ID | NIH-10910867 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are obese individuals who may be experiencing cardiovascular issues or insulin resistance.
✕Less likely to help
Patients who are not obese or do not have related cardiovascular conditions may not benefit from this research.
What this research studies
This research investigates how increasing muscle mass can help resolve blood vessel dysfunction caused by obesity. It focuses on understanding the mechanisms behind how fat accumulation in muscles affects insulin signaling and contributes to cardiometabolic diseases. The study aims to explore the potential of pharmacological interventions that could mimic the benefits of exercise, especially for patients who may struggle with physical activity due to age or other factors. By examining the relationship between muscle health and blood vessel function, the research seeks to identify new treatment strategies for obesity-related health issues.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve cardiovascular health in obese patients by enhancing muscle mass and function.
How similar studies have gone: Previous research has shown that exercise can improve cardiovascular health in obese patients, suggesting that similar pharmacological approaches may also be effective.
Where this research is happening
-
Augusta University
Augusta, United States Active
Researchers
- Principal investigator: Speese, Andrew — Augusta University
- Study coordinator: Speese, Andrew
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.