Increasing immune response through angiotensin converting enzyme
ACE and myeloid cell metabolism
['FUNDING_R01'] · CEDARS-SINAI MEDICAL CENTER · NIH-11012260
This study is looking at how boosting a protein called ACE in certain immune cells might help improve the body's defense against illnesses, and it could lead to new ways to strengthen the immune system for people facing different health challenges.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CEDARS-SINAI MEDICAL CENTER (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-11012260 on ClinicalTrials.gov |
What this research studies
This research investigates how enhancing the expression of angiotensin converting enzyme (ACE) in myeloid cells can improve the immune response. By examining both human and mouse models, the study aims to understand how myeloid cells adapt to immune challenges by increasing ACE production. The researchers will explore the metabolic changes that occur as a result of increased ACE, particularly focusing on how this affects ATP levels and overall immune function. The findings could lead to new strategies for boosting immune responses in various conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that involve impaired immune responses or those who may benefit from enhanced immune function.
Not a fit: Patients with conditions unrelated to immune response or those who are not affected by ACE-related pathways may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for conditions where the immune response is critical, such as infections and autoimmune diseases.
How similar studies have performed: Previous research has shown promising results in enhancing immune responses through metabolic modulation, suggesting potential success for this approach.
Where this research is happening
LOS ANGELES, UNITED STATES
- CEDARS-SINAI MEDICAL CENTER — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BERNSTEIN, KENNETH E — CEDARS-SINAI MEDICAL CENTER
- Study coordinator: BERNSTEIN, KENNETH E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.