Including African and Hispanic communities in Alzheimer's genetics
Recruitment and Retention for Alzheimer's Disease Diversity Genetic Cohorts in the ADSP (READD-ADSP)
This project will enroll people of African and Hispanic ancestry and collect genetic samples to better understand Alzheimer's risk in those communities.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-11380119 on NIH RePORTER |
What this research studies
You would be invited to join through trusted community and clinic partners who use culturally sensitive approaches to build trust and keep people involved. Participants will give health information and a blood or saliva sample, which will be genotyped and combined with other data to look for genetic risk factors. The effort aims to enroll about 13,000 diverse participants and link their genetic information to Alzheimer’s and related dementia diagnoses. Findings will be shared with the broader research community to help improve diagnosis and future treatments for under-represented groups.
Who could benefit from this research
Good fit: Adults of African, African American, African Caribbean, or Hispanic/Latino ancestry, especially those with Alzheimer’s disease, related dementias, or a family history, would be ideal candidates.
Not a fit: People who are exclusively of European ancestry or who do not wish to provide genetic samples are unlikely to benefit directly from this specific effort.
Why it matters
Potential benefit: If successful, this work could reveal genetic risk factors that improve diagnosis, risk prediction, and treatment options for African and Hispanic ancestry communities affected by Alzheimer's.
How similar studies have performed: Previous genetic studies in African American groups have found different risk signals (for example, ABCA7 and APOE effects) but were underpowered, so this larger, community-focused effort builds on promising but incomplete findings.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: Pericak-Vance, Margaret a. — University of Miami School of Medicine
- Study coordinator: Pericak-Vance, Margaret a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.