In vivo regulation of cell trafficking and the extracellular matrix (C. elegans)
Official title: In vivo regulation of cell trafficking and the extracellular matrix
Funded at University of Wyoming · NIH-11355452 · Data updated 2026-11-12
Aims to understand how cell movement and the surrounding extracellular matrix are controlled in a living organism, using C. elegans to uncover mechanisms that may relate to cancer biology.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wyoming NIH-funded |
| Lab location | 1 site (Laramie, United States) |
| Project start | July 1, 2020 |
| Project end | June 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $570,775 |
| NIH project number | 5R35GM136236-07 |
| Project ID | NIH-11355452 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to patients directly; basic research in model organisms.
✕Less likely to help
No direct patient involvement in this non-human study.
What this research studies
This project studies how cells move and how their surrounding matrix is organized in living worms. By focusing on two conserved pathways, researchers will look at membrane trafficking, actin dynamics, and how the epidermal extracellular matrix is shaped during development. The work could reveal new biological links between cell movement, lipid transport, and tissue remodeling that are relevant to cancer biology.
Why it matters
Potential benefit: If successful, findings could illuminate fundamental processes of cell movement and tissue structure that influence cancer progression and metastasis.
How similar studies have gone: Prior work in related systems suggests these pathways are important for membrane trafficking and tissue remodeling, supporting potential relevance to human disease.
Where this research is happening
-
University of Wyoming
Laramie, United States Active
Researchers
- Principal investigator: Fay, David S — University of Wyoming
- Study coordinator: Fay, David S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.