In-vivo MRI test to detect cerebral amyloid angiopathy in older adults
Official title: In-vivo MRI-based prediction of cerebral amyloid angiopathy in community-based older adults
Funded at Rush University Medical Center · NIH-11448905 · Data updated 2026-11-12
A new MRI-based method aims to identify cerebral amyloid angiopathy (CAA) in community-dwelling older adults, helping clinicians understand risk and guide care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rush University Medical Center NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | September 1, 2026 |
| Project end | May 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $656,503 |
| NIH project number | 1R01AG097950-01A1 |
| Project ID | NIH-11448905 on NIH RePORTER |
Who could benefit from this research
✓Could help
Older adults, especially those with or at risk for Alzheimer’s disease, who are able to undergo MRI and participate in follow-up assessments.
✕Less likely to help
Those unable to have MRI scans or follow-up visits may not benefit from this research.
What this research studies
This project will use advanced MRI methods to detect CAA in older adults living in communities, not just in clinics. By combining different MRI scans with pathology data, researchers hope to build a reliable in-vivo classifier for CAA. The goal is to improve early detection of CAA-related risks that can affect cognitive health and treatment decisions in Alzheimer’s disease. Participation would involve imaging and study procedures that fit into routine assessments for older adults with or at risk for Alzheimer’s disease.
Why it matters
Potential benefit: If successful, the approach could lead to earlier and more accurate detection of CAA, potentially informing treatment choices and monitoring for complications.
How similar studies have gone: Previous work supports the value of multimodal MRI for brain pathology, with this study aiming to translate that into in-vivo CAA detection.
Where this research is happening
-
Rush University Medical Center
Chicago, United States Active
Researchers
- Principal investigator: Arfanakis, Konstantinos — Rush University Medical Center
- Study coordinator: Arfanakis, Konstantinos
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.