Improving wound healing in diabetes by reprogramming immune cells
Reprogramming Macrophages to Improve Vascular Healing in Diabetes
This study is looking at how changing certain immune cells in the body can help wounds heal better for people with diabetes by promoting blood vessel growth, and it aims to find new ways to improve healing for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Providence VA Medical Center NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project ID | NIH-10930036 on NIH RePORTER |
What this research studies
This research investigates how reprogramming macrophages, a type of immune cell, can enhance the healing of wounds in individuals with diabetes. The study focuses on understanding the role of inflammatory signals in macrophages that promote blood vessel growth, which is crucial for effective wound healing. By exploring the molecular mechanisms involved, particularly the influence of certain cytokines, the research aims to identify new therapeutic strategies to improve healing outcomes for patients. The approach includes both laboratory experiments and potential applications in clinical settings.
Who could benefit from this research
Good fit: Ideal candidates for this research are veterans with diabetes who experience impaired wound healing.
Not a fit: Patients without diabetes or those who do not have issues with wound healing may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for wound healing in diabetic patients, reducing complications and enhancing quality of life.
How similar studies have performed: Other research has shown promising results in manipulating immune cell functions to improve healing, suggesting that this approach could be effective.
Where this research is happening
Providence, United States
- Providence VA Medical Center — Providence, United States (Active)
Researchers
- Principal investigator: Morrison, Alan Ross — Providence VA Medical Center
- Study coordinator: Morrison, Alan Ross
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.