Improving wound healing in diabetes by reprogramming immune cells
Official title: Reprogramming Macrophages to Improve Vascular Healing in Diabetes
Funded at Providence VA Medical Center · NIH-10930036 · Data updated 2026-11-12
This study is looking at how changing certain immune cells in the body can help wounds heal better for people with diabetes by promoting blood vessel growth, and it aims to find new ways to improve healing for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Providence VA Medical Center NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project start | July 1, 2021 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| NIH project number | 5I01CX002231-04 |
| Project ID | NIH-10930036 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are veterans with diabetes who experience impaired wound healing.
✕Less likely to help
Patients without diabetes or those who do not have issues with wound healing may not benefit from this research.
What this research studies
This research investigates how reprogramming macrophages, a type of immune cell, can enhance the healing of wounds in individuals with diabetes. The study focuses on understanding the role of inflammatory signals in macrophages that promote blood vessel growth, which is crucial for effective wound healing. By exploring the molecular mechanisms involved, particularly the influence of certain cytokines, the research aims to identify new therapeutic strategies to improve healing outcomes for patients. The approach includes both laboratory experiments and potential applications in clinical settings.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for wound healing in diabetic patients, reducing complications and enhancing quality of life.
How similar studies have gone: Other research has shown promising results in manipulating immune cell functions to improve healing, suggesting that this approach could be effective.
Where this research is happening
-
Providence VA Medical Center
Providence, United States Active
Researchers
- Principal investigator: Morrison, Alan Ross — Providence VA Medical Center
- Study coordinator: Morrison, Alan Ross
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.