Improving wound healing by targeting neutrophils in the body.
Official title: Targeting neutrophil clearance to harness myeloid responses for wound healing.
Funded at Upstate Medical University · NIH-10916173 · Data updated 2026-11-12
This study is looking at how a type of white blood cell called neutrophils can be used to help heal stubborn wounds in people with obesity and diabetes, and it aims to create a special nano-drug that makes these cells work better for faster healing.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Upstate Medical University NIH-funded |
| Lab location | 1 site (Syracuse, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $340,999 |
| NIH project number | 5R01GM144624-02 |
| Project ID | NIH-10916173 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from chronic wounds, particularly those with obesity or diabetes.
✕Less likely to help
Patients with acute wounds or those without metabolic conditions like obesity or diabetes may not benefit from this research.
What this research studies
This research investigates how neutrophils, a type of white blood cell, can be targeted to improve wound healing, particularly in patients with chronic wounds influenced by obesity and diabetes. The study will explore the mechanisms of neutrophil clearance in the bone marrow and how this process affects the body's ability to heal wounds. By using both mouse models and human samples, the researchers aim to develop a nano-drug that can modify myeloid responses to enhance healing. The approach combines biological insights with biomedical engineering to create potential new treatments for chronic wounds.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve wound healing for patients with chronic conditions.
How similar studies have gone: Other research has shown promise in targeting immune responses for wound healing, suggesting that this approach could be effective.
Where this research is happening
-
Upstate Medical University
Syracuse, United States Active
Researchers
- Principal investigator: Urao, Norifumi — Upstate Medical University
- Study coordinator: Urao, Norifumi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.