Improving ways to prevent cervical cancer for women with HIV in Botswana
Botswana CASCADE Clinical Trials Site
This project tries new ways to find and treat early cervical changes to prevent cancer in women living with HIV in Botswana.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11393518 on NIH RePORTER |
What this research studies
If you take part, the team will offer HPV self-sampling and screening options outside traditional clinics, including during antenatal visits, to make initial testing easier to get. If your test is positive, the study will try different approaches and technologies to manage and treat precancers while limiting risks and strain on the health system. The project will also work to improve access so more women complete treatment and follow-up. The site will run and join clinical trials that compare treatment methods like different ablation techniques to find what works best for women with HIV.
Who could benefit from this research
Good fit: Women living with HIV in Botswana who are due for cervical cancer screening, have a positive HPV or screening test, or are seeking precancer treatment (including pregnant women seen in antenatal care) are the main candidates.
Not a fit: People who are not women, who do not live in or cannot travel to Botswana, who do not have HIV, or who already have advanced invasive cervical cancer are unlikely to be eligible or to get direct benefit from this project.
Why it matters
Potential benefit: If successful, these approaches could lower cervical cancer deaths by finding and treating precancers earlier for women living with HIV.
How similar studies have performed: HPV self-sampling and screen-and-treat programs have shown promise in other settings, but there is less evidence specifically in women living with HIV in southern Africa, so this work builds on promising approaches while testing them in this context.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Dryden-Peterson, Scott — Brigham and Women's Hospital
- Study coordinator: Dryden-Peterson, Scott
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.