Improving walking and balance in people with multiple sclerosis

High-Intensity, dynamic-stability gait training in people with multiple sclerosis

NIH-funded research Marquette University · NIH-10889098

This study is testing a fun new training program that helps people with multiple sclerosis improve their walking and balance by using treadmill exercises with some balance challenges, so they can move better in their daily lives.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionMarquette University NIH-funded
Lab location1 site (Milwaukee, United States)
Project IDNIH-10889098 on NIH RePORTER

What this research studies

This research aims to enhance walking function and stability in individuals with multiple sclerosis (MS) through a unique training program that combines high-intensity exercise with balance challenges. Participants will engage in treadmill walking while experiencing balance perturbations, which will help them develop better neuromuscular strategies for maintaining posture. The program is designed to improve both walking speed and distance, as well as overall mobility in everyday life. The study will assess the effects of this training approach in both controlled laboratory settings and real-world environments.

Who could benefit from this research

Good fit: Ideal candidates for this research are individuals diagnosed with mild to moderate multiple sclerosis who experience mobility and balance challenges.

Not a fit: Patients with severe multiple sclerosis or those who are unable to participate in physical activity may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could significantly improve mobility and quality of life for patients with multiple sclerosis.

How similar studies have performed: Previous studies have shown promising results with high-intensity training and balance interventions in other neurological disorders, suggesting potential success for this approach in MS.

Where this research is happening

Milwaukee, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.