Improving walking ability after leg artery surgery for patients with peripheral artery disease
Official title: IMProving mobility After revasCularizaTion in Peripheral Artery Disease: the IMPACT PAD Trial
Funded at Northwestern University at Chicago · NIH-10885321 · Data updated 2026-11-12
This study is looking at whether doing exercises at home and taking a supplement called inorganic nitrate can help people with peripheral artery disease walk better after they've had surgery to improve blood flow in their legs, making it easier for them to stay active and feel better overall.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | September 17, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $1,264,646 |
| NIH project number | 1UG3HL169565-01A1 |
| Project ID | NIH-10885321 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are patients with peripheral artery disease who are undergoing lower extremity revascularization and experience walking impairments.
✕Less likely to help
Patients who do not have peripheral artery disease or those with limb-threatening ischemia may not benefit from this research.
What this research studies
This research investigates how home-based exercise and inorganic nitrate supplementation can enhance walking performance in patients with peripheral artery disease (PAD) who have undergone lower extremity revascularization. The study aims to determine if these interventions can provide better outcomes compared to surgery alone. By focusing on improving mobility, the research seeks to make exercise more accessible for patients who find supervised programs burdensome. The approach combines clinical procedures with dietary supplementation to potentially improve recovery and quality of life.
Why it matters
Potential benefit: If successful, this research could lead to improved walking ability and overall mobility for patients recovering from leg artery surgery.
How similar studies have gone: Previous research has shown that combining revascularization with supervised exercise can improve walking performance, suggesting that this home-based approach may also be effective.
Where this research is happening
-
Northwestern University at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Mcdermott, Mary Mcgrae — Northwestern University at Chicago
- Study coordinator: Mcdermott, Mary Mcgrae
Related research
Other NIH-funded projects on the same topics.
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Low-dose colchicine to reduce vascular risk in people with peripheral artery disease
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-
Gamified home walking program to help seniors with peripheral artery disease improve walking and quality of life
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Fatty clues in leg arteries: how fat burning in mitochondria affects PAD and muscle health
This project looks at how fat metabolism in leg muscles relates to weakness and tissue damage in people with peripheral artery disease and aims to find new ways to help them.
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Enhancing muscle energy to help leg function in PAD
A study to boost how muscle mitochondria work in people with peripheral artery disease to improve walking and leg function.
-
Low-dose colchicine for people with peripheral artery disease to reduce heart and limb risks
A large international study will test whether a low daily dose of colchicine can lower heart and limb complications for people with peripheral artery disease.
-
Low-dose colchicine for reducing vascular risk in people with PAD
A large international study will test whether a daily low dose of colchicine can lower heart and limb-related risks for people with peripheral artery disease.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.