Improving vocal fold function after recurrent laryngeal nerve injury
Central modulation-paired motor rehabilitation for recurrent laryngeal nerve injury
This study is looking at a new way to help people with vocal fold paralysis, caused by nerve injuries, by using electrical stimulation to improve how their vocal cords move, which can make it easier for them to swallow and speak.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Dallas NIH-funded |
| Lab location | 1 site (Richardson, United States) |
| Project ID | NIH-10936848 on NIH RePORTER |
What this research studies
This research investigates how to enhance vocal fold movement in patients who have suffered recurrent laryngeal nerve injuries, which can lead to vocal fold paralysis. The approach involves using electrical stimulation to the vagus nerve to potentially reorganize motor pathways in the brain, thereby improving the function of the laryngeal muscles. By focusing on central nervous system modulation, the research aims to restore better control over vocal fold movement, which is crucial for safe swallowing and effective communication. The study will utilize animal models to explore these mechanisms before translating findings to human applications.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced recurrent laryngeal nerve injuries resulting in vocal fold paralysis.
Not a fit: Patients without recurrent laryngeal nerve injuries or those with other unrelated vocal disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved vocal function and reduced risk of aspiration pneumonia for patients with recurrent laryngeal nerve injuries.
How similar studies have performed: Previous studies have shown promise in using electrical stimulation to improve motor function in other nerve injury models, suggesting potential for success in this novel approach.
Where this research is happening
Richardson, United States
- University of Texas Dallas — Richardson, United States (Active)
Researchers
- Principal investigator: Shembel, Adrianna — University of Texas Dallas
- Study coordinator: Shembel, Adrianna
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.