Improving vocal fold function after recurrent laryngeal nerve injury
Official title: Central modulation-paired motor rehabilitation for recurrent laryngeal nerve injury
Funded at University of Texas Dallas · NIH-10936848 · Data updated 2026-11-12
This study is looking at a new way to help people with vocal fold paralysis, caused by nerve injuries, by using electrical stimulation to improve how their vocal cords move, which can make it easier for them to swallow and speak.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Dallas NIH-funded |
| Lab location | 1 site (Richardson, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $618,001 |
| NIH project number | 1R01DC021990-01 |
| Project ID | NIH-10936848 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced recurrent laryngeal nerve injuries resulting in vocal fold paralysis.
✕Less likely to help
Patients without recurrent laryngeal nerve injuries or those with other unrelated vocal disorders may not benefit from this research.
What this research studies
This research investigates how to enhance vocal fold movement in patients who have suffered recurrent laryngeal nerve injuries, which can lead to vocal fold paralysis. The approach involves using electrical stimulation to the vagus nerve to potentially reorganize motor pathways in the brain, thereby improving the function of the laryngeal muscles. By focusing on central nervous system modulation, the research aims to restore better control over vocal fold movement, which is crucial for safe swallowing and effective communication. The study will utilize animal models to explore these mechanisms before translating findings to human applications.
Why it matters
Potential benefit: If successful, this research could lead to improved vocal function and reduced risk of aspiration pneumonia for patients with recurrent laryngeal nerve injuries.
How similar studies have gone: Previous studies have shown promise in using electrical stimulation to improve motor function in other nerve injury models, suggesting potential for success in this novel approach.
Where this research is happening
-
University of Texas Dallas
Richardson, United States Active
Researchers
- Principal investigator: Shembel, Adrianna — University of Texas Dallas
- Study coordinator: Shembel, Adrianna
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.