Improving virus treatments for brain tumors
Development of murine glioblastoma model for oncolytic HSV therapy
This project aims to create better mouse models to test new virus-based treatments for aggressive brain tumors.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Augusta University NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project ID | NIH-11135302 on NIH RePORTER |
What this research studies
We are working to build improved mouse models that can accurately mimic aggressive brain tumors, known as Grade IV glioblastoma. These new models will help us test how well a special type of virus, called oncolytic HSV-1, can fight these tumors and if it is safe. Current animal models have limitations, making it hard to fully understand how these viruses interact with the tumor and the body's immune system. By creating a more realistic model, we hope to speed up the development of these promising new therapies for patients.
Who could benefit from this research
Good fit: Patients with aggressive brain tumors, such as glioblastoma, could eventually benefit from the new treatments developed using these improved models.
Not a fit: Patients whose conditions are not related to aggressive brain tumors or who do not respond to virus-based therapies may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to faster and more effective testing of new virus-based therapies, bringing us closer to better treatments for patients with aggressive brain tumors.
How similar studies have performed: Oncolytic HSV-1 therapy has shown success in treating metastatic melanoma and has received conditional approval for recurrent glioblastoma in Japan, with several other similar viruses currently being investigated.
Where this research is happening
Augusta, United States
- Augusta University — Augusta, United States (Active)
Researchers
- Principal investigator: Kaur, Balveen — Augusta University
- Study coordinator: Kaur, Balveen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.