Improving vaccine effectiveness through extended dosing
Official title: "Extended dosing" immunization to enhance humoral immunity to next-generation vaccines
Funded at Scripps Research Institute, the · NIH-11238769 · Data updated 2026-11-12
This study is looking at a new way to give vaccines that involves multiple doses over two weeks to see if it can help your body make stronger defenses against infections like COVID-19 and HIV, and you might have the chance to participate in this exciting research!
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | February 14, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $454,147 |
| NIH project number | 7R01AI175489-03 |
| Project ID | NIH-11238769 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who are at risk for infections like COVID-19 or HIV and are seeking enhanced vaccine protection.
✕Less likely to help
Patients who are not at risk for these infections or who have already received effective vaccinations may not benefit from this research.
What this research studies
This research investigates how a new immunization technique, called 'extended dosing', can enhance the body's immune response to vaccines. By administering multiple doses of a vaccine over a two-week period, the study aims to improve the production of high-affinity antibodies that are crucial for fighting off infections like COVID-19 and HIV. The approach focuses on optimizing the germinal center response, which is essential for developing long-lasting immunity. Patients may be involved in trials to assess the effectiveness of this innovative vaccination strategy.
Why it matters
Potential benefit: If successful, this research could lead to more effective vaccines that provide stronger and longer-lasting immunity against various infectious diseases.
How similar studies have gone: Previous research has shown promising results with similar approaches to optimizing vaccine responses, indicating potential for success in this novel method.
Where this research is happening
-
Scripps Research Institute, the
La Jolla, United States Active
Researchers
- Principal investigator: Irvine, Darrell J — Scripps Research Institute, the
- Study coordinator: Irvine, Darrell J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.