Improving vaccine effectiveness through extended dosing
"Extended dosing" immunization to enhance humoral immunity to next-generation vaccines
['FUNDING_R01'] · SCRIPPS RESEARCH INSTITUTE, THE · NIH-11238769
This study is looking at a new way to give vaccines that involves multiple doses over two weeks to see if it can help your body make stronger defenses against infections like COVID-19 and HIV, and you might have the chance to participate in this exciting research!
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SCRIPPS RESEARCH INSTITUTE, THE (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11238769 on ClinicalTrials.gov |
What this research studies
This research investigates how a new immunization technique, called 'extended dosing', can enhance the body's immune response to vaccines. By administering multiple doses of a vaccine over a two-week period, the study aims to improve the production of high-affinity antibodies that are crucial for fighting off infections like COVID-19 and HIV. The approach focuses on optimizing the germinal center response, which is essential for developing long-lasting immunity. Patients may be involved in trials to assess the effectiveness of this innovative vaccination strategy.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who are at risk for infections like COVID-19 or HIV and are seeking enhanced vaccine protection.
Not a fit: Patients who are not at risk for these infections or who have already received effective vaccinations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective vaccines that provide stronger and longer-lasting immunity against various infectious diseases.
How similar studies have performed: Previous research has shown promising results with similar approaches to optimizing vaccine responses, indicating potential for success in this novel method.
Where this research is happening
LA JOLLA, UNITED STATES
- SCRIPPS RESEARCH INSTITUTE, THE — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: IRVINE, DARRELL J — SCRIPPS RESEARCH INSTITUTE, THE
- Study coordinator: IRVINE, DARRELL J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus