Improving vaccine effectiveness monitoring for respiratory and gastrointestinal illnesses in children

IP21-002 Enhanced Surveillance for New Vaccine Preventable Diseases

NIH-funded research Vanderbilt University Medical Center · NIH-11046457

This study is looking at how well vaccines for illnesses like the flu and COVID-19 work to protect young children from serious respiratory and stomach infections, so we can make sure they stay healthy and safe.

Quick facts

Grant typeU01 cooperative agreement
Study typeNIH-funded research
Funding institutionVanderbilt University Medical Center NIH-funded
Lab location1 site (Nashville, United States)
Project IDNIH-11046457 on NIH RePORTER

What this research studies

This research focuses on enhancing surveillance for acute respiratory illness (ARI) and acute gastroenteritis (AGE), which are major causes of death in young children. It aims to monitor the effectiveness of vaccines against these illnesses, particularly influenza and SARS-CoV-2, by assessing disease burden, causative pathogens, and vaccine impact. The study will involve rigorous, prospective data collection to understand how well vaccines protect children and to inform public health strategies. By tracking changes in pathogens and vaccine effectiveness over time, the research seeks to improve vaccination strategies and outcomes for pediatric populations.

Who could benefit from this research

Good fit: Ideal candidates for this research are young children, particularly those who are at risk for ARI and AGE, including those eligible for influenza and SARS-CoV-2 vaccinations.

Not a fit: Patients who are not children or those who have already been vaccinated against the specific pathogens being studied may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved vaccine strategies that significantly reduce the incidence of severe respiratory and gastrointestinal diseases in children.

How similar studies have performed: Previous research has shown success in monitoring vaccine effectiveness for influenza and other diseases, indicating that this approach is both relevant and necessary.

Where this research is happening

Nashville, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.