Improving urine test accuracy to reduce unnecessary antibiotic use.
Official title: A Randomized Controlled Trial of a Diagnostic Stewardship Intervention to Reduce Inappropriate Antibiotic Use for Urinary Tract Infections in Primary Care
Funded at Baylor College of Medicine · NIH-11087571 · Data updated 2026-11-12
This study is working to make urine tests for urinary tract infections more accurate by helping patients understand how to collect their samples correctly, especially if they face language or understanding challenges, so they can get the right treatment without unnecessary antibiotics.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | August 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $457,805 |
| NIH project number | 5R01HS029489-03 |
| Project ID | NIH-11087571 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients who are experiencing symptoms of urinary tract infections and are seeking care in primary care settings.
✕Less likely to help
Patients who do not have urinary tract infection symptoms or those who are not receiving care in primary care settings may not benefit from this research.
What this research studies
This research focuses on enhancing the accuracy of urine cultures, which are commonly used to diagnose urinary tract infections (UTIs). It aims to develop a patient education intervention that addresses barriers to proper urine sample collection, such as language differences and health literacy. By engaging stakeholders and incorporating their feedback, the study seeks to reduce contamination rates in urine samples, thereby improving diagnostic outcomes and minimizing inappropriate antibiotic prescriptions. The intervention will be tested in primary care settings to ensure its effectiveness in real-world scenarios.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnoses of urinary tract infections and a reduction in unnecessary antibiotic use, ultimately combating antimicrobial resistance.
How similar studies have gone: Previous studies have shown mixed results in reducing urine contamination, but this research incorporates novel stakeholder engagement and pilot testing, making it a potentially innovative approach.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Grigoryan, Larisa — Baylor College of Medicine
- Study coordinator: Grigoryan, Larisa
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.