Improving understanding of lung cancer screening benefits and risks
Applying causal inference methods to improve estimation of the real-world benefits and harms of lung cancer screening
['FUNDING_R01'] · UNIV OF NORTH CAROLINA CHAPEL HILL · NIH-10878888
This study is looking at how well low-dose CT scans for lung cancer work in real life, especially for people aged 65 and older, to see if there are any differences in benefits and risks compared to those in clinical trials, and it aims to find ways to make screening easier and more effective for everyone.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF NORTH CAROLINA CHAPEL HILL (nih funded) |
| Locations | 1 site (CHAPEL HILL, UNITED STATES) |
| Trial ID | NIH-10878888 on ClinicalTrials.gov |
What this research studies
This research investigates the real-world effectiveness of lung cancer screening using low-dose computed tomography, particularly focusing on how its benefits and harms may differ in the general population compared to clinical trial participants. The study aims to gather evidence that reflects the experiences of individuals eligible for screening, especially those aged 65 and older. By analyzing data on screening uptake and adherence, the research seeks to identify barriers to effective screening and improve patient outcomes. The ultimate goal is to provide clearer guidance on lung cancer screening practices that can be applied in everyday clinical settings.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals aged 65 and older who are eligible for lung cancer screening.
Not a fit: Patients who are not eligible for lung cancer screening or those who are younger than 65 years may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved lung cancer screening protocols that better reflect the needs and experiences of older adults, potentially reducing mortality rates.
How similar studies have performed: Previous studies have shown that low-dose computed tomography can reduce lung cancer mortality, but this research aims to explore its effectiveness in a broader, real-world context, making it a novel approach.
Where this research is happening
CHAPEL HILL, UNITED STATES
- UNIV OF NORTH CAROLINA CHAPEL HILL — CHAPEL HILL, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LUND, JENNIFER — UNIV OF NORTH CAROLINA CHAPEL HILL
- Study coordinator: LUND, JENNIFER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.