Improving understanding of HIV treatment impacts on disease progression
Official title: Developing Statistical Methods on Event History Data Subject to Data Complexities for HIV Disease Progression and Policy Evaluation
Funded at University of Kentucky · NIH-10810823 · Data updated 2026-11-12
This study is looking at how starting HIV treatment right away, as recommended by the WHO, affects people with HIV, and it aims to find better ways to understand how the disease progresses and how different groups are impacted, so that everyone can get the best care possible.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project start | March 16, 2023 |
| Project end | February 28, 2026 |
| Funding year | 2024 |
| Award (this year) | $200,288 |
| NIH project number | 5R21AI177008-02 |
| Project ID | NIH-10810823 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals living with HIV, particularly those diagnosed after the implementation of the Treat-All guidelines.
✕Less likely to help
Patients who were diagnosed with HIV before the Treat-All guidelines were implemented may not benefit directly from this research.
What this research studies
This research focuses on evaluating the effects of the WHO's Treat-All guidelines, which recommend immediate antiretroviral therapy for all individuals diagnosed with HIV. By analyzing extensive data from the International epidemiology Database to Evaluate AIDS, the study aims to develop new statistical methods to better understand HIV disease progression and the implications of treatment policies. The research will address previous limitations by utilizing a larger, multi-regional dataset to explore how different populations are affected by these treatment guidelines. Patients may benefit from improved treatment strategies based on the findings.
Why it matters
Potential benefit: If successful, this research could lead to more effective HIV treatment protocols that enhance patient outcomes.
How similar studies have gone: Previous research has shown promise in using large datasets to evaluate treatment impacts, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Kentucky
Lexington, United States Active
Researchers
- Principal investigator: Zhang, Hongbin — University of Kentucky
- Study coordinator: Zhang, Hongbin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.