Improving ultrasound treatment for liver tissue destruction
Official title: Aberration Correction for Histotripsy Ablation of Liver
Funded at University of Michigan at Ann Arbor · NIH-11078718 · Data updated 2026-11-12
This study is working on improving a special ultrasound treatment for liver problems that uses sound waves to safely break down unhealthy tissue, making it more accurate and effective for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | May 1, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $557,355 |
| NIH project number | 5R01CA282200-02 |
| Project ID | NIH-11078718 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with liver conditions requiring ablation therapy.
✕Less likely to help
Patients with conditions that do not involve liver tissue or those who are not candidates for ablation therapy may not benefit from this research.
What this research studies
This research focuses on enhancing a non-invasive ultrasound technique called histotripsy, which uses intense bursts of acoustic energy to break down liver tissue. The study aims to address two main challenges: accurately targeting the treatment area and correcting sound wave distortions caused by varying tissue properties. By developing advanced ultrasound imaging methods and aberration correction techniques, the research seeks to improve the effectiveness and safety of liver ablation procedures. Patients may benefit from a more precise and effective treatment option for liver conditions.
Why it matters
Potential benefit: If successful, this research could provide patients with a safer and more effective non-invasive treatment for liver diseases.
How similar studies have gone: Previous pilot trials have shown promising results for histotripsy in liver ablation, indicating potential for success with these enhanced techniques.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Hall, Timothy L — University of Michigan at Ann Arbor
- Study coordinator: Hall, Timothy L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.