Improving tuberculosis testing for people living with HIV and sepsis
Evaluation of novel tuberculosis LAM assays among people living with HIV and sepsis
This study is looking for ways to improve how we diagnose tuberculosis (TB) in people living with HIV who also have sepsis, by testing new urine tests that are easier to use than traditional methods, so if you join, you could help make it easier for others to get diagnosed and treated faster.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-10669787 on NIH RePORTER |
What this research studies
This research focuses on enhancing the diagnosis of tuberculosis (TB) in individuals living with HIV, particularly those experiencing sepsis. It aims to evaluate new urinary assays that can detect TB more effectively, using readily available urine samples instead of sputum, which can be difficult to obtain. The study will compare the performance of existing and novel assays, including a new method that processes urine samples to improve test accuracy. By participating, patients may contribute to the development of better diagnostic tools that could lead to earlier and more accurate TB detection.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are also experiencing symptoms of sepsis.
Not a fit: Patients who do not have HIV or are not presenting with sepsis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate and timely diagnoses of tuberculosis in vulnerable populations, ultimately improving patient outcomes.
How similar studies have performed: Previous research has shown promise in improving TB diagnostics using similar urinary assays, indicating potential for success in this novel approach.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Thomas, Tania a — University of Virginia
- Study coordinator: Thomas, Tania a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.