Improving tuberculosis diagnosis in HIV-infected children using a new urine test
Enhanced POC assay for TB in HIV-infected children based on the ultrasensitive detection of the urinary form of the lipoarabinomannan antigen
This study is working on a new, better test to help find tuberculosis in children who also have HIV by looking for a special marker in their urine, which could make it easier to catch the disease early and save lives.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project ID | NIH-10813025 on NIH RePORTER |
What this research studies
This research focuses on developing a more effective diagnostic test for tuberculosis (TB) in children who are also infected with HIV. The team is investigating a specific biomarker found in urine, known as lipoarabinomannan (LAM), which can indicate the presence of TB. By enhancing the sensitivity and specificity of a new lateral flow assay, the researchers aim to create a test that can accurately detect TB in young patients, potentially saving lives. The study builds on previous findings and aims to meet the World Health Organization's standards for optimal TB diagnostics.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who are infected with HIV and are suspected of having tuberculosis.
Not a fit: Patients who are not infected with HIV or who are older than 11 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier and more accurate diagnosis of TB in HIV-infected children, significantly improving treatment outcomes.
How similar studies have performed: Previous research has shown promise in using urinary biomarkers for TB diagnosis, but this specific approach is innovative and aims to enhance existing methods.
Where this research is happening
Newark, UNITED STATES
- Rutgers Biomedical and Health Sciences — Newark, United States (Active)
Researchers
- Principal investigator: Pinter, Abraham — Rutgers Biomedical and Health Sciences
- Study coordinator: Pinter, Abraham
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.