Improving treatments for tuberculosis using multiple drugs
Optimizing Multi-drug Mycobacterium tuberculosis Therapy for Rapid Sterilization and Resistance Suppression
['FUNDING_R01'] · UNIVERSITY OF FLORIDA · NIH-11010330
This study is looking for the best combinations of medicines to help treat tuberculosis more effectively, especially for patients with a lot of bacteria in their system, by testing these combinations in mice to see how well they work.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF FLORIDA (nih funded) |
| Locations | 1 site (GAINESVILLE, UNITED STATES) |
| Trial ID | NIH-11010330 on ClinicalTrials.gov |
What this research studies
This research focuses on optimizing combinations of multiple drugs to treat Mycobacterium tuberculosis (MTB) more effectively. By using advanced algorithms and mathematical models, the team aims to identify the best drug combinations that can rapidly kill the bacteria and prevent resistance from developing. The research involves testing these combinations in various models, including mice, to ensure they work effectively in different metabolic states of the bacteria. Patients with high bacterial loads may particularly benefit from these optimized regimens.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with tuberculosis, especially those with high bacterial loads.
Not a fit: Patients with drug-resistant tuberculosis who do not respond to current treatment regimens may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective tuberculosis treatments that reduce the time to recovery and lower the risk of drug resistance.
How similar studies have performed: Previous research has shown promise in optimizing drug combinations for tuberculosis, indicating that this approach has potential for success.
Where this research is happening
GAINESVILLE, UNITED STATES
- UNIVERSITY OF FLORIDA — GAINESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DRUSANO, GEORGE LOUIS — UNIVERSITY OF FLORIDA
- Study coordinator: DRUSANO, GEORGE LOUIS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.