Improving treatments for stroke patients
Official title: Strategy for Improving Stroke Treatment Response (SISTER) Trial
Funded at University of Cincinnati · NIH-11083854 · Data updated 2026-11-12
This study is looking for better and safer treatments for people who have had an ischemic stroke and can't use current options, by exploring how a molecule called a2-antiplasmin affects recovery and finding ways to block it to help reduce brain damage and improve healing.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $3,308,306 |
| NIH project number | 4UH3NS125023-02 |
| Project ID | NIH-11083854 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients who have experienced an ischemic stroke and are within the treatment window but do not qualify for current therapies.
✕Less likely to help
Patients who have had hemorrhagic strokes or those who are outside the treatment window may not benefit from this research.
What this research studies
This research focuses on developing safer and more effective treatments for patients suffering from ischemic stroke, particularly those who are not eligible for existing therapies. It investigates the role of a molecule called a2-antiplasmin, which has been linked to poor outcomes in stroke treatment. By exploring ways to inhibit a2-antiplasmin, the research aims to reduce brain injury and improve recovery for stroke patients. The approach includes both clinical and preclinical studies to assess the efficacy of new therapies.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options that significantly reduce disability and enhance recovery for stroke patients.
How similar studies have gone: Previous research has shown promising results in targeting a2-antiplasmin for improving stroke outcomes, indicating potential for success in this approach.
Where this research is happening
-
University of Cincinnati
Cincinnati, United States Active
Researchers
- Principal investigator: Khatri, Pooja — University of Cincinnati
- Study coordinator: Khatri, Pooja
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.