Improving treatments for organophosphate poisoning
Official title: Optimization of Substituted Phenoxyalkyl Pyridinium Oximes as Therapies for Organophosphate Poisoning
Funded at Mississippi State University · NIH-10906087 · Data updated 2026-11-12
This study is looking for better treatments for people who have been poisoned by certain toxic chemicals, aiming to create a new medicine that can help protect the brain and improve recovery after exposure.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mississippi State University NIH-funded |
| Lab location | 1 site (Mississippi State, United States) |
| Project start | August 1, 2021 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $657,302 |
| NIH project number | 5U01NS123255-04 |
| Project ID | NIH-10906087 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would include individuals who have been exposed to organophosphate compounds, such as those involved in accidents or terrorist attacks.
✕Less likely to help
Patients who have not been exposed to organophosphate compounds are unlikely to benefit from this research.
What this research studies
This research focuses on developing new therapies for organophosphate poisoning, which can occur from exposure to toxic nerve agents. Current treatments, like atropine and 2-PAM, are not always effective, especially in protecting the brain. The study aims to create a new type of oxime that can better penetrate the blood-brain barrier and improve survival rates and neurological outcomes in affected individuals. The research involves testing these new compounds in animal models to assess their effectiveness and safety.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for organophosphate poisoning, potentially saving lives and preserving brain function.
How similar studies have gone: Previous studies have shown that similar approaches using new oxime compounds have improved outcomes in animal models, indicating potential for success in this research.
Where this research is happening
-
Mississippi State University
Mississippi State, United States Active
Researchers
- Principal investigator: Chambers, Janice Elaine — Mississippi State University
- Study coordinator: Chambers, Janice Elaine
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.