Improving treatments for opioid use disorder
Official title: Select Late-Stage CMC, Non-clinical Studies, and Quality Programs to Accelerate NRS-033 Towards Pivotal Studies and Registration in Opioid Use Disorder
Funded at Nirsum Laboratories, INC. · NIH-11158855 · Data updated 2026-11-12
This study is looking for new and better ways to help people with opioid use disorder by creating more effective treatments that are easier to access and use, so that those struggling with addiction can have a better chance at recovery.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Nirsum Laboratories, INC. NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 1, 2024 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $4,947,774 |
| NIH project number | 5U01DA061643-02 |
| Project ID | NIH-11158855 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with opioid use disorder who are seeking effective treatment options.
✕Less likely to help
Patients who are not struggling with opioid use disorder or those who have already found effective treatment may not benefit from this research.
What this research studies
This research focuses on addressing the opioid use disorder (OUD) crisis by developing new treatment options beyond the currently available medications. It aims to enhance the effectiveness and accessibility of medications for opioid use disorder, particularly targeting the limitations of existing treatments like injectable naltrexone. The approach involves non-clinical studies and quality programs to accelerate the development of new therapies that could provide better outcomes for patients struggling with addiction. By investigating innovative solutions, the research seeks to improve treatment retention and patient acceptance.
Why it matters
Potential benefit: If successful, this research could lead to more effective and accessible treatments for individuals suffering from opioid use disorder.
How similar studies have gone: Other research has shown promise in developing new treatment approaches for opioid use disorder, indicating that innovative strategies can lead to significant advancements in patient care.
Where this research is happening
-
Nirsum Laboratories, INC.
New York, United States Active
Researchers
- Principal investigator: Shah, Nikej — Nirsum Laboratories, INC.
- Study coordinator: Shah, Nikej
Related research
Other NIH-funded projects on the same topics.
-
Systems analysis to improve opioid use disorder care after jail release (SAIA-MOUD)
A program to help people with opioid use disorder get better, faster, and safer care after they leave jail.
-
Precise epigenetic drugs for opioid addiction
A tiny, targeted drug approach is being developed to help people with opioid use disorder by rewriting the epigenetic signals in the brain to reduce cravings and relapse risk.
-
Increasing Access to Medications for Opioid Use Disorder for Unhoused Montanans
This project helps unhoused people in Montana get life-saving medicines for opioid use disorder through clinics connected to syringe service programs, a nurse-led MOUD model, and peer support.
-
Optimizing long-acting PrEP and opioid treatment for people in jails and prisons
This project tests a real-world approach to using long-acting PrEP and buprenorphine for HIV prevention and opioid treatment among incarcerated individuals and after release.
-
Scaling up medications for opioid use disorder in residential treatment programs
This grant studies how to help residential treatment programs provide medications for opioid use disorder to reduce overdoses after discharge, focusing on real-world settings and policies.
-
Increasing Capacity at a Native Community Clinic to Improve Opioid Care for urban AI/AN
This grant helps a Native American health clinic build its research capacity to better serve urban American Indian and Alaska Native people dealing with opioid use disorder and related health issues.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.