Improving Treatments for NUT Carcinoma
Overcoming Limitations of BETInhibition in NUT Carcinoma
This project aims to find new ways to treat NUT carcinoma, an aggressive cancer that mainly affects young people, by understanding how it grows and finding better drug targets.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11146610 on NIH RePORTER |
What this research studies
NUT carcinoma is a very aggressive cancer, especially in adolescents and young adults, with limited effective treatments. This project focuses on understanding how a specific protein, BRD4-NUT, helps this cancer grow by changing the cell's genetic material. While current treatments called BET inhibitors have shown some promise, they don't fully stop the cancer. Our goal is to discover additional ways the cancer grows, beyond what BET inhibitors address, so we can develop more effective therapies. We hope to identify new targets that, when combined with existing treatments, can significantly improve outcomes for patients.
Who could benefit from this research
Good fit: This research is focused on understanding and treating NUT carcinoma, particularly in adolescents and young adults.
Not a fit: Patients without NUT carcinoma would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to more effective treatments and improved survival rates for patients with NUT carcinoma.
How similar studies have performed: BET inhibitors have shown some clinical efficacy in NUT carcinoma, but this project seeks to overcome their limitations by identifying novel cooperative mechanisms.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: French, Christopher a — Brigham and Women's Hospital
- Study coordinator: French, Christopher a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.