Improving treatments for myeloid leukemia in children with Down syndrome
Official title: Enhancing treatments for myeloid leukemia associated with Down syndrome
Funded at Wayne State University · NIH-10878451 · Data updated 2026-11-12
This study is looking at how a common leukemia treatment works for kids with Down syndrome, focusing on how the leukemia cells interact with their bone marrow, to find better ways to help them respond to treatment and lower the chances of the cancer coming back.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $306,623 |
| NIH project number | 1R01CA290480-01 |
| Project ID | NIH-10878451 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years diagnosed with myeloid leukemia and Down syndrome.
✕Less likely to help
Patients with myeloid leukemia who do not have Down syndrome may not benefit from this specific research.
What this research studies
This research investigates how myeloid leukemia, particularly in children with Down syndrome, responds to treatments involving cytarabine. It focuses on understanding the interactions between leukemia cells and the bone marrow environment, specifically how endothelial cells influence treatment effectiveness and the potential for relapse. By studying these interactions, the research aims to uncover the molecular mechanisms that contribute to the high survival rates observed in these patients. The ultimate goal is to enhance treatment strategies and reduce the risk of relapse for children with this condition.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments and improved survival rates for children with myeloid leukemia associated with Down syndrome.
How similar studies have gone: Previous research has shown promising results in understanding leukemia treatment responses, but this specific focus on Down syndrome is relatively novel.
Where this research is happening
-
Wayne State University
Detroit, United States Active
Researchers
- Principal investigator: Taub, Jeffrey Warren — Wayne State University
- Study coordinator: Taub, Jeffrey Warren
Related research
Other NIH-funded projects on the same topics.
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Enhancing treatments for myeloid leukemia with Down syndrome
This grant explores how bone marrow support cells affect treatment response in children with Down syndrome–related leukemia and aims to improve chemotherapy effectiveness.
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Preventing fatal infections in children with Down syndrome during ALL treatment
Aimed at reducing deadly infections in children with Down syndrome undergoing chemotherapy for acute lymphoblastic leukemia by finding biomarkers to tailor treatment and supportive care.
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Chronic health problems in children with Down syndrome who survived leukemia
This project looks at long-term health issues in kids with Down syndrome who have survived leukemia to understand what problems they may face later on.
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Better treatments for myeloid leukemia in children with Down syndrome
This project looks at how bone marrow blood-vessel cells influence why chemotherapy works so well for children with Down syndrome who develop myeloid leukemia.
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Long-term health after leukemia in children with Down syndrome
This project looks at ongoing medical and thinking problems in children with Down syndrome who had acute leukemia compared with children with Down syndrome who never had cancer.
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Preventing deadly infections in children with Down syndrome during leukemia treatment
This project looks for blood markers that can identify children with Down syndrome and acute lymphoblastic leukemia who are at high risk for life-threatening infections so doctors can offer extra protection early.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.