Improving treatments for brain injury in newborns from low-resource countries
Official title: Optimizing Neuroprotective Strategies for HIE in Low- and Middle-Resource Settings (LMIC neuroprotection)
Funded at University of Washington · NIH-11046390 · Data updated 2026-11-12
This study is looking for new ways to protect the brains of babies who have suffered from a lack of oxygen at birth, especially in places where regular treatments might not be available, and it aims to find helpful medicines that can improve their recovery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | June 18, 2025 |
| Project end | February 28, 2030 |
| Funding year | 2025 |
| Award (this year) | $615,478 |
| NIH project number | 1R01HD114573-01A1 |
| Project ID | NIH-11046390 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are newborns and infants diagnosed with hypoxic-ischemic encephalopathy, particularly those from low- and middle-income countries.
✕Less likely to help
Patients who are not newborns or those who do not have a diagnosis of hypoxic-ischemic encephalopathy may not benefit from this research.
What this research studies
This research focuses on finding effective neuroprotective strategies for infants suffering from hypoxic-ischemic encephalopathy (HIE) due to perinatal asphyxia, particularly in low- and middle-income countries (LMICs). It aims to develop and test new therapies that are suitable for these settings, where standard treatments like therapeutic hypothermia may not be feasible. By using innovative animal models that mimic the unique conditions faced by infants in LMICs, the research seeks to identify potential pharmacological agents that can mitigate brain injury and improve outcomes. The study will involve both laboratory experiments and behavioral assessments to evaluate the effectiveness of these treatments.
Why it matters
Potential benefit: If successful, this research could lead to improved survival rates and reduced neurodevelopmental impairments in infants affected by HIE in low-resource settings.
How similar studies have gone: Previous research has shown promise in developing neuroprotective strategies for HIE, but this specific approach tailored for LMICs is relatively novel.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Wood, Thomas — University of Washington
- Study coordinator: Wood, Thomas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.