Improving treatment strategies for opioid use disorder
Official title: OPTIMIZING RETENTION, DURATION AND DISCONTINUATION STRATEGIES FOR OPIOID USE DISORDER PHARMACOTHERAPY (CTN-0100). AUGUST 15, 2024 TO MARCH 31, 2028. N01DA-22-2253. TASK ORDER NO. 75N95024F00007 (TO23)
Funded at The Emmes Company, LLC · NIH-11220969 · Data updated 2026-11-12
This study is all about finding better ways to help people with opioid use disorder stick with their treatment, figure out how long they should stay on medication, and know when it’s the right time to stop taking it, all to support their recovery and health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | The Emmes Company, LLC NIH-funded |
| Lab location | 1 site (Rockville, United States) |
| Project start | August 15, 2024 |
| Project end | March 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $1,510,879 |
| NIH project number | 75N95022D00017-0-759502400007-1 |
| Project ID | NIH-11220969 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with opioid use disorder who are currently receiving or are eligible for pharmacotherapy.
✕Less likely to help
Patients who are not struggling with opioid use disorder or those who are not seeking treatment for their addiction may not benefit from this research.
What this research studies
This research focuses on enhancing the effectiveness of pharmacotherapy for individuals struggling with opioid use disorder. It aims to optimize strategies for retaining patients in treatment, determining the appropriate duration of therapy, and identifying the best times to discontinue medication. By employing a comprehensive approach, the research seeks to address the challenges faced by patients in managing their addiction and improving their overall health outcomes.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment protocols for opioid use disorder, ultimately helping patients achieve better recovery outcomes.
How similar studies have gone: Previous research has shown promising results in optimizing treatment strategies for opioid use disorder, indicating that this approach has the potential for success.
Where this research is happening
-
The Emmes Company, LLC
Rockville, United States Active
Researchers
- Principal investigator: Mccormack, Jennifer — The Emmes Company, LLC
- Study coordinator: Mccormack, Jennifer
Related research
Other NIH-funded projects on the same topics.
-
Systems analysis to improve opioid use disorder care after jail release (SAIA-MOUD)
A program to help people with opioid use disorder get better, faster, and safer care after they leave jail.
-
Precise epigenetic drugs for opioid addiction
A tiny, targeted drug approach is being developed to help people with opioid use disorder by rewriting the epigenetic signals in the brain to reduce cravings and relapse risk.
-
Increasing Access to Medications for Opioid Use Disorder for Unhoused Montanans
This project helps unhoused people in Montana get life-saving medicines for opioid use disorder through clinics connected to syringe service programs, a nurse-led MOUD model, and peer support.
-
Optimizing long-acting PrEP and opioid treatment for people in jails and prisons
This project tests a real-world approach to using long-acting PrEP and buprenorphine for HIV prevention and opioid treatment among incarcerated individuals and after release.
-
Scaling up medications for opioid use disorder in residential treatment programs
This grant studies how to help residential treatment programs provide medications for opioid use disorder to reduce overdoses after discharge, focusing on real-world settings and policies.
-
Increasing Capacity at a Native Community Clinic to Improve Opioid Care for urban AI/AN
This grant helps a Native American health clinic build its research capacity to better serve urban American Indian and Alaska Native people dealing with opioid use disorder and related health issues.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.