Improving treatment retention for patients using methadone and cocaine

Treating Polysubstance Use in Methadone Maintenance: Application of Novel Digital Technology

NIH-funded research Friends Research Institute, INC. · NIH-10588517

This study is testing a new app that helps people in methadone treatment for opioid use who also use cocaine by offering support and rewards for reaching their treatment goals, to see if it can help them stay in treatment longer and reduce the chances of relapse or overdose.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionFriends Research Institute, INC. NIH-funded
Lab location1 site (Baltimore, United States)
Project IDNIH-10588517 on NIH RePORTER

What this research studies

This research investigates a new digital therapy app designed to help patients who are undergoing methadone treatment for opioid use disorder and also use cocaine. The study will compare traditional treatment methods with the addition of the DynamiCare Health Contingency Management app, which provides automated support and rewards for achieving specific treatment goals. Participants will be monitored for their drug use and medication pickup, with the app offering financial incentives for meeting these targets over a 48-week period. The goal is to enhance retention in treatment and reduce the risk of relapse and overdose.

Who could benefit from this research

Good fit: Ideal candidates for this research are individuals receiving methadone treatment for opioid use disorder who also have a history of cocaine use.

Not a fit: Patients who are not currently using methadone or do not have a comorbidity of cocaine use may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved retention in methadone treatment and better outcomes for patients struggling with polysubstance use.

How similar studies have performed: Previous research has shown promise in using digital interventions for substance use treatment, suggesting that this approach could be effective.

Where this research is happening

Baltimore, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.