Improving treatment models for head and neck cancer
Radiogenomic Credentialing of Head and Neck Cancer Models
This study is working on creating better models of head and neck cancer to see how they respond to current and new treatments, which could help find more effective options for patients, especially those without HPV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Roswell Park Cancer Institute Corp NIH-funded |
| Lab location | 1 site (Buffalo, United States) |
| Project ID | NIH-10983756 on NIH RePORTER |
What this research studies
This research focuses on developing and validating new models of head and neck squamous cell carcinomas (HNSCC) that can better mimic human disease. By creating patient-derived and immunocompetent models, the research aims to systematically compare their responses to existing treatments and new therapies. The study will utilize both in vitro (lab-based) and in vivo (live organism) approaches to assess how these models respond to standard treatments and novel drugs. This could lead to more effective treatment strategies for patients with HNSCC, particularly those without HPV.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with head and neck squamous cell carcinoma, especially those who are HPV negative.
Not a fit: Patients with other types of cancers or those with HPV positive head and neck cancers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and outcomes for patients with head and neck cancer.
How similar studies have performed: Other research has shown promise in developing similar cancer models, indicating that this approach could be effective.
Where this research is happening
Buffalo, United States
- Roswell Park Cancer Institute Corp — Buffalo, United States (Active)
Researchers
- Principal investigator: Seshadri, Mukund — Roswell Park Cancer Institute Corp
- Study coordinator: Seshadri, Mukund
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.