Improving treatment for Type 2 diabetes using small molecules
Optimizing small molecule SWELL1-LRRC8 modulators to treat Type 2 diabetes
['FUNDING_R01'] · WASHINGTON UNIVERSITY · NIH-11084471
This study is exploring a new way to help people with Type 2 diabetes by using a special molecule called SN-401 that may improve how the body handles insulin and sugar, aiming to make it easier for you to manage your blood sugar and overall health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-11084471 on ClinicalTrials.gov |
What this research studies
This research focuses on a new approach to treat Type 2 diabetes by targeting a specific signaling pathway involving SWELL1. Researchers have discovered a small molecule modulator, SN-401, which enhances insulin sensitivity and secretion in diabetic models. The study aims to optimize this modulator to improve glucose regulation and overall metabolic health. By restoring SWELL1 signaling, the research seeks to address multiple organ dysfunctions associated with diabetes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Type 2 diabetes who struggle with insulin sensitivity and glucose regulation.
Not a fit: Patients who do not have Type 2 diabetes or those with other forms of diabetes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a novel treatment that significantly improves blood sugar control and metabolic health for patients with Type 2 diabetes.
How similar studies have performed: Other research has shown promise in targeting similar pathways for diabetes treatment, indicating potential for success with this novel approach.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SAH, RAJAN — WASHINGTON UNIVERSITY
- Study coordinator: SAH, RAJAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: adult onset diabetes, Adult-Onset Diabetes Mellitus