Improving treatment for trichomonas (a common sexually transmitted infection) in women and men
Refining Trichomonas vaginalis treatment in women and men.
This project compares whether a single-dose secnidazole pill or current metronidazole dosing cures trichomonas infections better in women and men.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tulane University of Louisiana NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project ID | NIH-11290822 on NIH RePORTER |
What this research studies
From your perspective, the team will compare the usual metronidazole schedules with a single-dose secnidazole option to see which clears the infection more often. If you join, you would take the assigned oral medication and come back for follow-up visits and tests to confirm whether the infection is gone. The research includes both women and men because past studies focused mostly on women and left treatment questions for men unanswered. The researchers will also record side effects and any repeat infections to find safer, easier treatment options.
Who could benefit from this research
Good fit: Adults diagnosed with Trichomonas vaginalis who can safely take oral nitroimidazole medications would be the ideal candidates.
Not a fit: People without a trichomonas infection, those allergic to nitroimidazoles, or those for whom oral antibiotics are unsafe may not receive benefit from participation.
Why it matters
Potential benefit: If successful, this work could produce a simpler, better-tolerated single-dose option that cures more infections and reduces onward transmission.
How similar studies have performed: Previous trials showed multi-dose metronidazole beats single-dose metronidazole in women, and a recent trial found single-dose secnidazole was better than placebo in women, but there is little data for men.
Where this research is happening
New Orleans, United States
- Tulane University of Louisiana — New Orleans, United States (Active)
Researchers
- Principal investigator: Kissinger, Patricia J — Tulane University of Louisiana
- Study coordinator: Kissinger, Patricia J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.